منابع مشابه
Actin switches in phagocytosis.
Exposure of phagocytes to non-spherical particles has provided evidence for multiple actions of the actin system in force generation. For the uptake of long cylindrical particles, a "motile actin clamp" mechanism is proposed. When a phagocyte is engaged with an hour-glass-shaped particle, it exerts contractile activity alternatively at the far end of the particle or at its concave region. Phago...
متن کاملPhagocytosis and the actin cytoskeleton.
The process of engulfing a foreign particle - phagocytosis - is of fundamental importance for a wide diversity of organisms. From simple unicellular organisms that use phagocytosis to obtain their next meal, to complex metazoans in which phagocytic cells represent an essential branch of the immune system, evolution has armed cells with a fantastic repertoire of molecules that serve to bring abo...
متن کاملAmphiphysin 1 Is Important for Actin Polymerization during Phagocytosis□D
Amphiphysin 1 is involved in clathrin-mediated endocytosis. In this study, we demonstrate that amphiphysin 1 is essential for cellular phagocytosis and that it is critical for actin polymerization. Phagocytosis in Sertoli cells was induced by stimulating phosphatidylserine receptors. This stimulation led to the formation of actin-rich structures, including ruffles, phagocytic cups, and phagosom...
متن کاملPhosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis
The Rho GTPases play a critical role in initiating actin polymerization during phagocytosis. In contrast, the factors directing the disassembly of F-actin required for fission of the phagocytic vacuole are ill defined. We used fluorescent chimeric proteins to monitor the dynamics of association of actin and active Cdc42 and Rac1 with the forming phagosome. Although actin was found to disappear ...
متن کاملSWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis
Actin plays a critical role during the early stages of pathogenic microbe internalization by immune cells. In this study, we identified a key mechanism of actin filament tethering and stabilization to the surface of phagosomes in human dendritic cells. We found that the actin-binding protein SWAP70 is specifically recruited to nascent phagosomes by binding to the lipid phosphatidylinositol (3,4...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2011
ISSN: 1942-0889
DOI: 10.4161/cib.4.3.15041